Selected publications
M. Botou, V. Yalelis, P. Lazou, I. Zantza, K. Papakostas, V. Charalambous, E. Mikros, E. Flemetakis, and S. Frillingos, Specificity profile of NAT/NCS2 purine transporters in Sinorhizobium (Ensifer) meliloti, Mol. Microbiol. (2020) in press.
https://www.ncbi.nlm.nih.gov/pubmed/32198949
M. Botou, P. Lazou, K. Papakostas, G. Lambrinidis, T. Evangelidis, E. Mikros, and S. Frillingos, Insight on specificity of uracil permeases of the NAT/NCS2 family from analysis of the transporter encoded in the pyrimidine utilization operon of Escherichia coli. Mol. Microbiol. 108, 204-219 (2018)
http://www.ncbi.nlm.nih.gov/pubmed/29437264
E. Karena, E. Tatsaki, G. Lambrinidis, E. Mikros, and S. Frillingos, Analysis of conserved NCS2 motifs in the Escherichia coli xanthine permease XanQ, Mol. Microbiol. 98, 502-517 (2015) http://www.ncbi.nlm.nih.gov/pubmed/26192456
K. Papakostas, M. Botou, and S. Frillingos, Functional identification of the hypoxanthine/guanine transporters YjcD and YgfQ and the adenine transporters PurP and YicO of Escherichia coli K-12, J. Biol. Chem. 288, 36827-36840 (2013).
http://www.ncbi.nlm.nih.gov/pubmed/24214977
E. Karena and S. Frillingos, The role of transmembrane segment TM3 in the xanthine permease XanQ of Escherichia coli, J. Biol. Chem. 286, 39595-39605 (2011).
http://www.ncbi.nlm.nih.gov/pubmed/21917919
E. Georgopoulou, G. Mermelekas, E. Karena, and S. Frillingos, «Purine substrate recognition by the nucleobase-ascorbate transporter motif in the YgfO xanthine permease: Asn-325 binds and Ala-323 senses substrate», J. Biol. Chem. 285, 19422-19433 (2010).
http://www.ncbi.nlm.nih.gov/pubmed/20406814
H. R. Kaback, R. Dunten, S. Frillingos, P. Venkatesan, I. Kwaw, W. Zhang, and N. Ermolova, «Site-directed alkylation and the alternating access model for LacY», Proc. Natl. Acad. Sci. USA 104,491-494 (2007).
http://www.ncbi.nlm.nih.gov/pubmed/17172438
P. Karatza, and S. Frillingos, «Cloning and functional characterization of two bacterial members of the NAT/NCS2 family in Escherichia coli», Mol. Membr. Biol. 22, 251-261 (2005).
http://www.ncbi.nlm.nih.gov/pubmed/16096268
S. Frillingos, M. Sahin-Tόth, J. Wu, and H. R. Kaback, «Cys-scanning mutagenesis: a novel approach to structure-function relationships in membrane proteins», FASEB J. 12, 1281-1299 (1998).
http://www.ncbi.nlm.nih.gov/pubmed/9761772